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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1987-6-10
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|
pubmed:abstractText |
The synthesis of some selected PAF-acether homologues with an alkoxy-chain length from C1 to C20 in position 1 is described. All agonist activities are closely correlated among themselves and with the calculated fatty-chain hydrophobicity. After a discussion on recent published results and comparison with our data, we conclude that the ether oxide function is absolutely essential at the glycerol 1-position for potent agonist activity and that potency correlates well with hydrophobicity parameters. We indicate the importance of steric and configurational constraints.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
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pubmed:issn |
0022-2623
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
30
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
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|
pubmed:pagination |
792-7
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|
pubmed:dateRevised |
2008-11-21
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|
pubmed:meshHeading |
pubmed-meshheading:3572968-Animals,
pubmed-meshheading:3572968-Blood Pressure,
pubmed-meshheading:3572968-Bronchi,
pubmed-meshheading:3572968-Chemical Phenomena,
pubmed-meshheading:3572968-Chemistry,
pubmed-meshheading:3572968-Constriction, Pathologic,
pubmed-meshheading:3572968-Guinea Pigs,
pubmed-meshheading:3572968-Male,
pubmed-meshheading:3572968-Molecular Conformation,
pubmed-meshheading:3572968-Platelet Activating Factor,
pubmed-meshheading:3572968-Platelet Aggregation,
pubmed-meshheading:3572968-Rabbits,
pubmed-meshheading:3572968-Rats,
pubmed-meshheading:3572968-Rats, Inbred Strains,
pubmed-meshheading:3572968-Structure-Activity Relationship,
pubmed-meshheading:3572968-Thrombocytopenia
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pubmed:year |
1987
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|
pubmed:articleTitle |
Structure-activity relationship in PAF-acether. 3. Hydrophobic contribution to agonistic activity.
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|
pubmed:publicationType |
Journal Article,
Comparative Study
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