Linked Life Data

3572483

Source:http://linkedlifedata.com/resource/pubmed/id/3572483

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1987-6-25
pubmed:abstractText
We raised 8 macaque monkeys with chronic atropinization of one eye throughout the first 6-10 months after birth. This rearing procedure produces retinal image blur, with the most pronounced contrast attenuation occurring at high spatial frequencies. Measurements of contrast sensitivity were made using behavioral methods in 6 monkeys and evoked potential methods in 2 monkeys. The results showed that this rearing procedure produced long-term deficits in the contrast sensitivity and spatial resolution of the atropinized eye, which were not due to residual losses in accommodative capacity. There was considerable interanimal variation in the magnitude of the effects on visual performance. Similar losses in visual performance are seen in some forms of human amblyopia. Rearing monkeys with chronic instillation of atropine therefore provides a nonhuman primate model for studying the underlying neural mechanisms of anisometropic amblyopia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1318-26
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effects of early unilateral blur on the macaque's visual system. I. Behavioral observations.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't