|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1987-5-27
|
|
pubmed:abstractText |
An asymptomatic 16-year-old boy was found to have Wilson's disease without Kayser-Fleischer rings. Liver biopsy showed chronic active hepatitis with 1025 micrograms copper/g dry weight. After 19 months of d-penicillamine therapy, the liver histology became almost normal and the copper content decreased to 238 micrograms/g dry weight. The liver specimens obtained before and after treatment were studied by X-ray probe microanalysis. After treatment, both copper and sulfur decreased in hepatocellular lysosomes. The estimated molar ratio of the decreased copper to the decreased sulfur was 32/100. These figures suggest that lysosomal copper exists in the form of metallothionein.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0435-1339
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
633-7
|
|
pubmed:dateRevised |
2004-11-17
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|
pubmed:meshHeading |
pubmed-meshheading:3569749-Adolescent,
pubmed-meshheading:3569749-Biopsy,
pubmed-meshheading:3569749-Calcium,
pubmed-meshheading:3569749-Copper,
pubmed-meshheading:3569749-Electron Probe Microanalysis,
pubmed-meshheading:3569749-Hepatolenticular Degeneration,
pubmed-meshheading:3569749-Humans,
pubmed-meshheading:3569749-Iron,
pubmed-meshheading:3569749-Lysosomes,
pubmed-meshheading:3569749-Male,
pubmed-meshheading:3569749-Metabolic Detoxication, Drug,
pubmed-meshheading:3569749-Penicillamine,
pubmed-meshheading:3569749-Phosphorus,
pubmed-meshheading:3569749-Sulfur
|
|
pubmed:year |
1986
|
|
pubmed:articleTitle |
A copper-sulfur complex in the liver of a patient with Wilson's disease.
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|
pubmed:publicationType |
Journal Article,
Case Reports
|
