| pubmed-article:3569168 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3569168 | lifeskim:mentions | umls-concept:C0024554 | lld:lifeskim |
| pubmed-article:3569168 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:3569168 | lifeskim:mentions | umls-concept:C2698297 | lld:lifeskim |
| pubmed-article:3569168 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:3569168 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:3569168 | lifeskim:mentions | umls-concept:C0752095 | lld:lifeskim |
| pubmed-article:3569168 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:3569168 | lifeskim:mentions | umls-concept:C0043902 | lld:lifeskim |
| pubmed-article:3569168 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3569168 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:3569168 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3569168 | pubmed:dateCreated | 1987-6-17 | lld:pubmed |
| pubmed-article:3569168 | pubmed:abstractText | Groups of male B6C3F1 mice (N = 12) were exposed to ambient air or to gaseous 1,3-butadiene (BD) at 6.25, 62.5, and 625 ppm for 10 exposure days (6 hr + T90/day). Exposure to BD induced in bone marrow: 1) a significant increase in the frequency of chromosomal aberrations (CA); 2) a significant elevation in the frequency of sister chromatid exchanges (SCE); 3) a significant lengthening of the average generation time (AGT); 4) a significant depression in the mitotic index (MI); and, as measured in the peripheral blood, 5) a significant increase in the proportion of circulating polychromatic erythrocytes (%PCE), and 6) a significant increase in the level of micronucleated PCE (MN-PCE) and micronucleated normochromatic erythrocytes (MN-NCE). The most sensitive indicator of genotoxic damage was the frequency of SCE (significant at 6.25 ppm), followed by MN-PCE levels (significant at 62.5 ppm), and then by CA and MN-NCE frequencies (significant at 625 ppm). The most sensitive measure of cytotoxic damage was AGT (significant at 62.5 ppm), followed by %PCE (significant at 625 ppm), and then by MI (significant by trend test only). Because each cytogenetic endpoint was evaluated in every animal, a correlation analysis was conducted to evaluate the degree of concordance among the various indicators of genotoxic and cytotoxic damage. The extent of concordance ranged from a very good correlation between the induction of MN-PCE and the induction of SCE (correlation coefficient r = 0.9562) to the lack of a significant correlation between the depression in the MI and any other endpoint (r less than 0.37). | lld:pubmed |
| pubmed-article:3569168 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3569168 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3569168 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3569168 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3569168 | pubmed:issn | 0192-2521 | lld:pubmed |
| pubmed-article:3569168 | pubmed:author | pubmed-author:BoucherRR | lld:pubmed |
| pubmed-article:3569168 | pubmed:author | pubmed-author:TiceR RRR | lld:pubmed |
| pubmed-article:3569168 | pubmed:author | pubmed-author:ShelbyM DMD | lld:pubmed |
| pubmed-article:3569168 | pubmed:author | pubmed-author:MoorBB | lld:pubmed |
| pubmed-article:3569168 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3569168 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:3569168 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3569168 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3569168 | pubmed:pagination | 235-50 | lld:pubmed |
| pubmed-article:3569168 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:3569168 | pubmed:meshHeading | pubmed-meshheading:3569168-... | lld:pubmed |
| pubmed-article:3569168 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3569168 | pubmed:articleTitle | Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. | lld:pubmed |
| pubmed-article:3569168 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3569168 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3569168 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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