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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1987-6-5
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pubmed:abstractText |
The immunohistochemical distribution of the glial fibrillary acidic protein (GFAP), a marker of glial filaments, was studied on coronal sections of the globus pallidus, the area CA4 of the hippocampus and the arcuate nucleus of the hypothalamus, 3 estrogen-sensitive areas of the rat brain. The number and the surface density of the GFAP-immunoreactive cells were evaluated in 6 adult ovariectomized rats injected with a single dose (20 mg/kg) of estradiol valerate (OVX + E2 rats) and in 6 ovariectomized littermates injected with vehicle (OVX rats). Two days after the injection, a similar distribution of the GFAP was observed in the arcuate nucleus of OVX + E2 rats when compared to OVX rats, whereas a significantly (P less than 0.001) increased surface density of GFAP immunoreactive material was observed in the globus pallidus and hippocampus of estradiol-treated rats. Since the number of GFAP-positive cells was unchanged by the estradiol injection, the enhanced surface density of GFAP immunoreactive material in the hippocampus and globus pallidus suggest a possible influence of estradiol on GFAP-immunoreactive glial processes.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
17
|
pubmed:volume |
406
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
348-51
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3567632-Animals,
pubmed-meshheading:3567632-Arcuate Nucleus,
pubmed-meshheading:3567632-Astrocytes,
pubmed-meshheading:3567632-Brain,
pubmed-meshheading:3567632-Estradiol,
pubmed-meshheading:3567632-Female,
pubmed-meshheading:3567632-Glial Fibrillary Acidic Protein,
pubmed-meshheading:3567632-Globus Pallidus,
pubmed-meshheading:3567632-Hippocampus,
pubmed-meshheading:3567632-Ovariectomy,
pubmed-meshheading:3567632-Rats
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pubmed:year |
1987
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pubmed:articleTitle |
Estradiol--induced redistribution of glial fibrillary acidic protein immunoreactivity in the rat brain.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|