Linked Life Data

3566839

Source:http://linkedlifedata.com/resource/pubmed/id/3566839

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1987-4-29
pubmed:abstractText
The tetrachlorodecaoxygen anion complex (TCDO, Oxoferin) given intravenously 1 h after intravenous infection of mice with Candida albicans increased the host's resistance gradually in doses up to 3.1 mumol/kg body weight (b.w.). Above this level, the stimulatory effect decreased, turning to an inhibition at a dose of 18.6 mumol/kg b.w. TCDO. Repeated applications of the optimum single dose had no cumulative effect. In experimental infections with the strictly anaerobic Peptostreptococcus intermedius, TCDO ameliorated the course of the infection not only at a dose of 3.1 mumol/kg b.w. but also at a higher dose of 12.4 mumol/kg b.w. TCDO, which in the Candida sepsis model fell into the range of defence inhibition. A single dose of 3.1 mumol/kg b.w. TCDO also revealed to be the optimum dose to increase the humoral immune response evaluated by the number of immunoglobulin (Ig)M and IgG forming spleen cells after sensitization with sheep red blood cells (SRBC). The same results were obtained, regardless of whether TCDO had been given at the time of immunization or thereafter. The higher single dose of 18.6 mumol/kg b.w. TCDO did not show this effect but was not inhibitory either. Cellular immune reactions evaluated by the footpad swelling test and SRBC as antigen were found considerably enhanced whether TCDO was given once or repeatedly at a dose of 3.1 mumol/kg b.w., whereas single doses of 18.6 mumol/kg or repeated doses of 9.3 mumol/kg induced a certain inhibition.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1778-82
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Increased resistance towards two systemic experimental infections by tetrachlorodecaoxygen anion complex. Possible implications of cellular and humoral immunity.
pubmed:publicationType
Journal Article