Linked Life Data

3566693

Source:http://linkedlifedata.com/resource/pubmed/id/3566693

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-5-18
pubmed:abstractText
To characterize the role of fatty acid oxidation in the control of food intake, we investigated the effect of 2-mercaptoacetate, which inhibits fatty acid oxidation, on meal patterns and cumulative food intake in rats. Rats were fed either a medium fat (MF, 18% fat) or a low fat (LF, 3.3% fat) diet. Mercaptoacetate (400 mumole/kg body wt), intraperitoneally injected in the middle of the bright or at the onset of the dark phase of the diurnal lighting cycle, increased cumulative food intake in MF rats by shortening the latency to eat after injection and the duration of the subsequent intermeal interval (IMI) without affecting the size of the first meal. Mercaptoacetate, injected in the middle of the bright phase, reduced the latency to eat but did not affect the duration of the subsequent IMI or cumulative food intake in LF rats. A higher dose of mercaptoacetate (600 mumole/kg body wt), initially increased and later decreased cumulative food intake in MF rats. The initial increase in food intake was due to shorter IMIs; the subsequent decrease in food intake was due to smaller meals after mercaptoacetate injection than after control injection. The results indicate that a drop in fatty acid oxidation caused by mercaptoacetate triggers a meal. This implicates fatty acid oxidation in the maintenance of postprandial satiety.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0163-1047
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-16
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Role of fatty acid oxidation in control of meal pattern.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't