Linked Life Data

3566293

Source:http://linkedlifedata.com/resource/pubmed/id/3566293

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 2
pubmed:dateCreated
1987-4-27
pubmed:abstractText
Zinc is essential for the proliferation of tumor cells. It is suggested that tumor cell growth is inhibited by zinc deficiency in Yoshida sarcoma-bearing rats fed on a zinc-deficient diet. Clinically applicable methods for inducing a zinc-deficient condition in tumor cells were investigated for the therapeutic application of the above phenomenon. As one of these methods, the administration of progesterone to tumor-bearing rats was tried experimentally, and the changes in the zinc content of the tumor tissue and tumor growth were studied and compared with those of tumors in a control group. Progesterone is a competitive inhibitor of glucocorticoid which stimulates zinc uptake by tumor cells. In Yoshida sarcoma-or AH 109A-bearing rats, a tendency of reduction in zinc content in the tumor tissue and inhibition of the tumor growth in the progesterone-administered group was observed in comparison with the control group, although this was not very significant.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0385-0684
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
801-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[Hormonal control of zinc uptake in tumor cells].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't