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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1987-5-21
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pubmed:abstractText |
The pharmacokinetics and bioavailability of an in vitro controlled release amoxicillin formulation were studied in nine healthy volunteers, in comparison with an intravenous injection and a conventional tablet. The experiment was designed in a crossover fashion. The volunteers received the three formulations on separate occasions. The antibiotic was measured in plasma using a microbiological method. The absolute bioavailability of the two solid dosage forms was estimated comparing non-compartmental parameters. The results indicated that there was no correlation between the in vitro dissolution rate and the pharmacokinetic behavior in the body.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0174-4879
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
25
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
97-100
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3557736-Adult,
pubmed-meshheading:3557736-Amoxicillin,
pubmed-meshheading:3557736-Biological Availability,
pubmed-meshheading:3557736-Delayed-Action Preparations,
pubmed-meshheading:3557736-Female,
pubmed-meshheading:3557736-Half-Life,
pubmed-meshheading:3557736-Humans,
pubmed-meshheading:3557736-Injections, Intravenous,
pubmed-meshheading:3557736-Kinetics,
pubmed-meshheading:3557736-Male,
pubmed-meshheading:3557736-Solubility,
pubmed-meshheading:3557736-Tablets
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pubmed:year |
1987
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pubmed:articleTitle |
Pharmacokinetics and bioavailability of a controlled release amoxicillin formulation.
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pubmed:publicationType |
Journal Article,
Comparative Study
|