Linked Life Data

3556553

Source:http://linkedlifedata.com/resource/pubmed/id/3556553

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-5-13
pubmed:abstractText
Effects of dibunol, isoptin and their combination were studied on 80 conscious rabbits with transient myocardial ischemia. Prophylactic (for 4 days before experiment in a dose of 20 mg/kg) and therapeutic (2 days, 40 mg/kg) intraperitoneal administration of dibunol resulted in a diminution of necrosis size and a decrease of the number of ventricular fibrillations in the period of the coronary artery occlusion. Administration of isoptin (0.4 mg/kg intravenously during transient ischemia) was followed by a restriction of necrotic focus. A combined therapeutic administration of dibunol and isoptin provided a significant diminution of myocardial necrosis size, the number of ventricular fibrillations and stabilized the level of malondialdehyde in the blood plasma. The role of peroxide destruction of membranes and calcium overload of cardiomyocytes in the pathogenesis of irreversible ischemic damage of the myocardium is discussed.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0014-8318
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
[Action of dibunol, isoptin and their combination in transitory myocardial ischemia in waking rabbits].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract