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rdf:type |
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lifeskim:mentions |
umls-concept:C0033684,
umls-concept:C0043393,
umls-concept:C0162508,
umls-concept:C0205147,
umls-concept:C0805701,
umls-concept:C0815047,
umls-concept:C1334043,
umls-concept:C1514562,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2697616
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pubmed:issue |
10
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pubmed:dateCreated |
1987-6-18
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pubmed:abstractText |
The product of the recently described oncogene jun shows significant amino acid sequence homology with the GCN4 yeast transcriptional activator protein. The similarity is restricted to the 66 carboxyl-terminal amino acids, thought to be the DNA-binding domain of the GCN4 protein. In these alpha-helix-permissive regions of the jun and GCN4 products there is also a lesser but still significant amino acid resemblance to the fos protein and a marginal degree of similarity to myc proteins. The amino acid sequence homology between GCN4 and jun gene products suggests that the jun protein may bind to DNA in a sequence-specific way and exert a regulatory function.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-2982161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-2998035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-3033666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-3083416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-3516410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-3530496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-3532321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-3907851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-3945547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-4358940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-6095062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-6100188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-6341997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-6351059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-642007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3554236-7280687
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3316-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:3554236-Amino Acid Sequence,
pubmed-meshheading:3554236-Binding Sites,
pubmed-meshheading:3554236-DNA,
pubmed-meshheading:3554236-DNA-Binding Proteins,
pubmed-meshheading:3554236-Fungal Proteins,
pubmed-meshheading:3554236-Genes, Fungal,
pubmed-meshheading:3554236-Humans,
pubmed-meshheading:3554236-Oncogenes,
pubmed-meshheading:3554236-Protein Kinases,
pubmed-meshheading:3554236-Proto-Oncogene Proteins,
pubmed-meshheading:3554236-Saccharomyces cerevisiae,
pubmed-meshheading:3554236-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:3554236-Sequence Homology, Nucleic Acid,
pubmed-meshheading:3554236-Transcription Factors,
pubmed-meshheading:3554236-ras Proteins
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pubmed:year |
1987
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pubmed:articleTitle |
Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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