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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1987-6-15
|
| pubmed:abstractText |
One hundred thirty-three infants and children with documented acute otitis media (OM) were randomized to receive the oral suspension of either amoxicillin-clavulanate potassium or cefaclor. Beta-lactamase-producing bacteria were found in 10.9 and 14.5% of subjects treated with amoxicillin-clavulanate potassium and cefaclor, respectively. Subjects were reexamined at 5, 10, 30, 60 and 90 days after the initiation of therapy and whenever signs/symptoms of acute otitis media recurred. All but two children had resolution of otalgia/otorrhea during the initial treatment period. The drug groups were not significantly different in the percentage of evaluable subjects with otitis media with effusion at each scheduled follow-up visit. Recurrence of acute OM/otorrhea [corrected] developed in a similar percentage of subjects in both treatment categories. Both subjects with and those without middle ear effusion at 10 days had approximately a 50% recurrence rate of subsequent middle ear disease. Adverse side effects/complaints, which occurred in significantly more children treated with amoxicillin-clavulanate potassium, were generally mild and primarily gastrointestinal.
|
| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amoxicillin,
http://linkedlifedata.com/resource/pubmed/chemical/Amoxicillin-Potassium Clavulanate...,
http://linkedlifedata.com/resource/pubmed/chemical/Cefaclor,
http://linkedlifedata.com/resource/pubmed/chemical/Cephalexin,
http://linkedlifedata.com/resource/pubmed/chemical/Clavulanic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0891-3668
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
265-71
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3554125-Acute Disease,
pubmed-meshheading:3554125-Amoxicillin,
pubmed-meshheading:3554125-Amoxicillin-Potassium Clavulanate Combination,
pubmed-meshheading:3554125-Cefaclor,
pubmed-meshheading:3554125-Cephalexin,
pubmed-meshheading:3554125-Child,
pubmed-meshheading:3554125-Child, Preschool,
pubmed-meshheading:3554125-Clavulanic Acids,
pubmed-meshheading:3554125-Clinical Trials as Topic,
pubmed-meshheading:3554125-Double-Blind Method,
pubmed-meshheading:3554125-Drug Combinations,
pubmed-meshheading:3554125-Earache,
pubmed-meshheading:3554125-Female,
pubmed-meshheading:3554125-Fever,
pubmed-meshheading:3554125-Humans,
pubmed-meshheading:3554125-Infant,
pubmed-meshheading:3554125-Male,
pubmed-meshheading:3554125-Otitis Media,
pubmed-meshheading:3554125-Otitis Media with Effusion,
pubmed-meshheading:3554125-Random Allocation,
pubmed-meshheading:3554125-Recurrence
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Amoxicillin-clavulanate potassium compared with cefaclor for acute otitis media in infants and children.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|