| pubmed-article:3550724 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3550724 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3550724 | lifeskim:mentions | umls-concept:C0030274 | lld:lifeskim |
| pubmed-article:3550724 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:3550724 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:3550724 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:3550724 | lifeskim:mentions | umls-concept:C0268070 | lld:lifeskim |
| pubmed-article:3550724 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3550724 | pubmed:dateCreated | 1987-4-29 | lld:pubmed |
| pubmed-article:3550724 | pubmed:abstractText | Free enkephalins (enk) and higher molecular weight enkephalin-containing peptides (enk-c-p) are present in the endocrine pancreas of rats, presumably in B cells. To determine whether these opioid peptides show dynamic alterations as insulin content of pancreas changes, we utilized a copper deficient rat model, in which the exocrine pancreas atrophies and the endocrine pancreas is "intact" and insulin (IRI) content increases. Dietary copper deficiency (-C) was produced in weanling male rats for 4 and 7 weeks. The deficient and copper supplemented (+C) groups were further subdivided to receive all dietary carbohydrate as either 62% fructose (F) or 62% starch (S). -CF rats showed the most severe deficiency. After 7 weeks, total units of pancreatic IRI in -CF were 7.5 +CF 2.1, -CS 7.9 and in +CS 2.8 (p less than 0.001). Pancreatic content of Met5- and Leu5-enk was measured in extracts which were purified on C-18 Seppaks with and without prior treatment with trypsin and carboxypeptidase B. -C animals showed progressive, significant increases in pancreatic content of Leu-enk-c-p, with a decrease in free Leu- and Met-enk (p less than 0.02-0.01). The pancreatic findings are compatible with a co-localization of enkephalins and insulin in the endocrine pancreas and are suggestive of co-regulation. | lld:pubmed |
| pubmed-article:3550724 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3550724 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3550724 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3550724 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3550724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3550724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3550724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3550724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3550724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3550724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3550724 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3550724 | pubmed:issn | 0196-9781 | lld:pubmed |
| pubmed-article:3550724 | pubmed:author | pubmed-author:RecantLL | lld:pubmed |
| pubmed-article:3550724 | pubmed:author | pubmed-author:BhathenaS JSJ | lld:pubmed |
| pubmed-article:3550724 | pubmed:author | pubmed-author:VoylesN RNR | lld:pubmed |
| pubmed-article:3550724 | pubmed:author | pubmed-author:FieldsMM | lld:pubmed |
| pubmed-article:3550724 | pubmed:author | pubmed-author:TimmersK IKI | lld:pubmed |
| pubmed-article:3550724 | pubmed:author | pubmed-author:ZalenskiCC | lld:pubmed |
| pubmed-article:3550724 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3550724 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:3550724 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3550724 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3550724 | pubmed:pagination | 1061-9 | lld:pubmed |
| pubmed-article:3550724 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:3550724 | pubmed:meshHeading | pubmed-meshheading:3550724-... | lld:pubmed |
| pubmed-article:3550724 | pubmed:meshHeading | pubmed-meshheading:3550724-... | lld:pubmed |
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| pubmed-article:3550724 | pubmed:meshHeading | pubmed-meshheading:3550724-... | lld:pubmed |
| pubmed-article:3550724 | pubmed:meshHeading | pubmed-meshheading:3550724-... | lld:pubmed |
| pubmed-article:3550724 | pubmed:meshHeading | pubmed-meshheading:3550724-... | lld:pubmed |
| pubmed-article:3550724 | pubmed:meshHeading | pubmed-meshheading:3550724-... | lld:pubmed |
| pubmed-article:3550724 | pubmed:articleTitle | Copper deficiency in rats increases pancreatic enkephalin-containing peptides and insulin. | lld:pubmed |
| pubmed-article:3550724 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3550724 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3550724 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3550724 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
