| pubmed-article:3546576 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3546576 | lifeskim:mentions | umls-concept:C0025919 | lld:lifeskim |
| pubmed-article:3546576 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:3546576 | lifeskim:mentions | umls-concept:C0023283 | lld:lifeskim |
| pubmed-article:3546576 | lifeskim:mentions | umls-concept:C1457869 | lld:lifeskim |
| pubmed-article:3546576 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3546576 | pubmed:dateCreated | 1987-4-13 | lld:pubmed |
| pubmed-article:3546576 | pubmed:abstractText | Local cellular responses to cutaneous infection with Leishmania mexicana amazonensis were examined in susceptible (BALB/c) and resistant (C57BL/6) mouse strains by immunocytochemical and electron microscopic studies. Infection during the first 8 wk in both animal strains was characterized by progressively enlarging lesions, epidermal thickening and ulceration, and accumulation of eosinophils and Ia+ infected macrophages. Healing of C57BL/6 mouse lesions began after 12 wk of infection and was associated with local influx of both Th (L3T4+) and T cytotoxic/suppressor (Lyt-2+) cells into the dermis, and Ia antigen expression on epidermal keratinocytes. T lymphocyte infiltration was marked and intracellular parasites were scarce by 21 wk of C57BL/6 infection. Similarly, granulomas in C57BL/6 livers contained L3T4+ and Lyt-2+ T lymphocytes and no visible intracellular parasites by 21 wk of infection. In contrast, BALB/c mouse lesions continued to enlarge and never healed. Throughout the entire course of infection, T lymphocyte influx into the heavily infected dermis was minimal. Keratinocyte Ia expression was absent in BALB/c lesions. BALB/c livers were heavily infected by 18 wk of cutaneous infection, with few demonstrable T lymphocytes. A systemic absence of T cells could not be demonstrated in BALB/c mice. Both L3T4+ and Lyt-2+ T cells were found in the peripheral blood in normal numbers in both mouse strains. Our results support the role of T cells as important local effector cells in the healing response of murine cutaneous leishmaniasis. We suggest that local T lymphocyte infiltration may provide lymphokines, particularly IFN-gamma, that can activate infected macrophages to destroy the intracellular parasites. Alternatively, T cells may play a cytotoxic role, killing infected macrophages and allowing local humoral factors to destroy released extracellular parasites. | lld:pubmed |
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| pubmed-article:3546576 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3546576 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3546576 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3546576 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3546576 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:3546576 | pubmed:author | pubmed-author:KaplanGG | lld:pubmed |
| pubmed-article:3546576 | pubmed:author | pubmed-author:CohnZ AZA | lld:pubmed |
| pubmed-article:3546576 | pubmed:author | pubmed-author:McElrathM JMJ | lld:pubmed |
| pubmed-article:3546576 | pubmed:author | pubmed-author:NusratAA | lld:pubmed |
| pubmed-article:3546576 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3546576 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3546576 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:3546576 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3546576 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3546576 | pubmed:pagination | 546-59 | lld:pubmed |
| pubmed-article:3546576 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3546576 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3546576 | pubmed:articleTitle | Cutaneous leishmaniasis. The defect in T cell influx in BALB/c mice. | lld:pubmed |
| pubmed-article:3546576 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3546576 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3546576 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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