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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1987-2-25
|
| pubmed:abstractText |
Paired liver biopsy specimens and serum samples from 76 patients with chronic hepatitis B virus (HBV) infection were taken for staining of hepatitis B core antigen (HBcAg) by immunoperoxidase and testing of HBV-DNA by a spot hybridization technique, respectively. Thirty-two tissue specimens showed positive staining for HBcAg in their hepatocytes. The two patients with diffuse HBcAg expression in liver tissue also had high serum concentrations of HBV-DNA (greater than 10 pg/10 microL). Among 30 patients with focal HBcAg distribution, 28 patients (93.3%) had measurable levels of serum HBV-DNA and 17 patients (60.7%) had high levels of serum HBV-DNA. Of 44 patients without hepatic HBcAg expression, only 12 patients (27.3%) had detectable serum HBV-DNA, and most patients (93.1% [11/12]) had low concentrations (less than 10 pg/10 microL). Nineteen patients had superimposed hepatitis D virus infection, and, of these, three patients (15.8%) had detectable serum HBV-DNA in low concentrations, while one of the three patients had stainable HBcAg in his hepatocytes with focal distribution. Two of the three patients with hepatitis A virus superinfection who had focal HBcAg expression in their liver tissue had serum HBV-DNA levels that were high during the acute phase of hepatitis A virus infection, and in one patient his serum HBV-DNA levels further increased from 10 pg/10 microL to 40 pg/10 microL during the recovery phase. Thus, measurement of serum HBV-DNA levels in patients with chronic HBV infection correlated well with their hepatic HBcAg expression, and both represent the precise status of HBV replication.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0003-9985
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
111
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
181-4
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3545139-Adolescent,
pubmed-meshheading:3545139-Adult,
pubmed-meshheading:3545139-Aged,
pubmed-meshheading:3545139-Biopsy, Needle,
pubmed-meshheading:3545139-Carrier State,
pubmed-meshheading:3545139-Chronic Disease,
pubmed-meshheading:3545139-DNA, Viral,
pubmed-meshheading:3545139-Female,
pubmed-meshheading:3545139-Hepatitis, Chronic,
pubmed-meshheading:3545139-Hepatitis A,
pubmed-meshheading:3545139-Hepatitis B,
pubmed-meshheading:3545139-Hepatitis B Core Antigens,
pubmed-meshheading:3545139-Hepatitis B virus,
pubmed-meshheading:3545139-Hepatitis D,
pubmed-meshheading:3545139-Humans,
pubmed-meshheading:3545139-Immunoenzyme Techniques,
pubmed-meshheading:3545139-Liver,
pubmed-meshheading:3545139-Male,
pubmed-meshheading:3545139-Middle Aged,
pubmed-meshheading:3545139-Taiwan
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Correlation between hepatic hepatitis B core antigen and serum hepatitis B virus-DNA levels in patients with chronic hepatitis B virus infections in Taiwan.
|
| pubmed:publicationType |
Journal Article
|