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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-3-23
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pubmed:abstractText |
The receptors for insulin and epidermal growth factor possess tyrosine-specific protein kinase activity which may play a role in mediating the biological actions of these two peptides. We have identified a 120 kDa glycoprotein (pp120) in rat liver plasma membranes which can be phosphorylated by the insulin receptor in a cell-free system and in intact cultured hepatoma cells. In the present report, we have demonstrated in a cell-free system that solubilized epidermal growth factor receptors can phosphorylate tyrosine residues in pp120.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
212
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
141-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:3542568-Animals,
pubmed-meshheading:3542568-Cell-Free System,
pubmed-meshheading:3542568-Epidermal Growth Factor,
pubmed-meshheading:3542568-Glycoproteins,
pubmed-meshheading:3542568-Insulin,
pubmed-meshheading:3542568-Male,
pubmed-meshheading:3542568-Membrane Proteins,
pubmed-meshheading:3542568-Microsomes, Liver,
pubmed-meshheading:3542568-Phosphorylation,
pubmed-meshheading:3542568-Protein-Tyrosine Kinases,
pubmed-meshheading:3542568-Rats,
pubmed-meshheading:3542568-Rats, Inbred Strains,
pubmed-meshheading:3542568-Receptor, Epidermal Growth Factor,
pubmed-meshheading:3542568-Receptor, Insulin
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pubmed:year |
1987
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pubmed:articleTitle |
Rat liver membranes contain a 120 kDa glycoprotein which serves as a substrate for the tyrosine kinases of the receptors for insulin and epidermal growth factor.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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