Linked Life Data

3541675

Source:http://linkedlifedata.com/resource/pubmed/id/3541675

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1987-1-28
pubmed:abstractText
Neocortical inhibition and neuronal morphology were studied in rats following chronic ethanol treatment (CET). In terminal acute experiments, spontaneous neuronal discharges in pair-fed and naive rats were inhibited by epicortical stimulation, a procedure known to produce postsynaptic inhibition. Few units in CET rats were inhibited by such stimulation. Cortical recurrent inhibition, indicated by a surface-negative potential in response to antidromic stimulation of the cerebral peduncle, was little affected by a challenge dose of ethanol, compared with the response in pair-fed animals. Recurrent inhibition involves inhibitory interneurons. CET apparently made inhibitory interneurons and inhibitory postsynaptic receptors less responsive to ethanol. Apical dendritic spines on some portions of pyramidal neurons increased in number with CET. This could reflect a compensatory growth in neurons not damaged by CET. The overall observations are consistent with ethanol affecting one or more specific systems of cortical motor control as opposed to its presumed general disinhibitory effect.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0145-6008
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
512-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effects of chronic ethanol treatment on neocortex.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.