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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1987-2-17
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pubmed:abstractText |
The clinical efficacy of four laboratory tests in detecting leptomeningeal metastases in 57 patients with breast carcinoma was assessed. The sensitivity and specificity of beta-glucuronidase, beta 2-microglobulin, carcinoembryonic antigen and lactate dehydrogenase in cerebrospinal fluid were determined. As a single test beta-glucuronidase was the most sensitive (93%) and specific (93%) for discriminating between leptomeningeal metastases and other CNS metastases from breast cancer. Lactate dehydrogenase was the next most useful marker. Both beta 2-microglobulin and carcinoembryonic antigen had a sensitivity of 60%. More specific results were achieved by combining beta-glucuronidase and lactate dehydrogenase. CSF beta-glucuronidase may be useful by itself and in combination with lactate dehydrogenase in the detection of leptomeningeal metastases from breast carcinoma.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-3525181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-3987058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-5034298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-573381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-5807872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-6157089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-6189578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-7212647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-7301610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-7420663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-7436807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-83592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540216-9728963
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-3050
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1246-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3540216-Adult,
pubmed-meshheading:3540216-Aged,
pubmed-meshheading:3540216-Arachnoid,
pubmed-meshheading:3540216-Breast Neoplasms,
pubmed-meshheading:3540216-Carcinoembryonic Antigen,
pubmed-meshheading:3540216-Female,
pubmed-meshheading:3540216-Glucuronidase,
pubmed-meshheading:3540216-Humans,
pubmed-meshheading:3540216-L-Lactate Dehydrogenase,
pubmed-meshheading:3540216-Meningeal Neoplasms,
pubmed-meshheading:3540216-Middle Aged,
pubmed-meshheading:3540216-Pia Mater,
pubmed-meshheading:3540216-beta 2-Microglobulin
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pubmed:year |
1986
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pubmed:articleTitle |
Sensitivity and specificity of single and combined tumour markers in the diagnosis of leptomeningeal metastasis from breast cancer.
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pubmed:publicationType |
Journal Article
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