|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1987-1-22
|
|
pubmed:abstractText |
The interaction of SCH 23390 with central serotonin 5-HT2 receptors was studied in vivo on [3H]spiperone binding and in vitro on [3H]ketanserin binding. SCH 23390 inhibited [3H]spiperone binding in rat frontal cortex with an ID50 of 1.5 mg/kg i.p., thus being equipotent to the two 5-HT2 antagonists cinanserin and methysergide. In vitro, SCH 23390 competed with [3H]ketanserin with an IC50 of 30 nM. These data indicate that SCH 23390 also binds with high affinity to 5-HT2 receptors in rat brain.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0014-2999
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
7
|
|
pubmed:volume |
129
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
367-70
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:3536532-Animals,
pubmed-meshheading:3536532-Benzazepines,
pubmed-meshheading:3536532-Brain,
pubmed-meshheading:3536532-Ketanserin,
pubmed-meshheading:3536532-Male,
pubmed-meshheading:3536532-Rats,
pubmed-meshheading:3536532-Receptors, Dopamine,
pubmed-meshheading:3536532-Receptors, Serotonin,
pubmed-meshheading:3536532-Spiperone,
pubmed-meshheading:3536532-Tissue Distribution
|
|
pubmed:year |
1986
|
|
pubmed:articleTitle |
The D-1 dopamine receptor antagonist SCH 23390 also interacts potently with brain serotonin (5-HT2) receptors.
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
