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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-12-18
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pubmed:abstractText |
Deposition of amyloid is the most constantly present alteration in the islets of Langerhans in type 2 diabetes mellitus and is also quite common in insulin-producing tumors of the pancreas and it is very likely that these two amyloids are identical. We have isolated amyloid fibrils from an insulin-secreting human tumour and purified the fibrillar protein. N-terminal amino acid sequence of the protein is unique and does not resemble insulin or its precursors. Instead it has about 50% homology with the neuropeptide CGRP (calcitonin gene related peptide).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-291X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
827-31
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:3535798-Amino Acid Sequence,
pubmed-meshheading:3535798-Amyloid,
pubmed-meshheading:3535798-Calcitonin Gene-Related Peptide,
pubmed-meshheading:3535798-Chromatography, High Pressure Liquid,
pubmed-meshheading:3535798-Humans,
pubmed-meshheading:3535798-Insulin,
pubmed-meshheading:3535798-Islets of Langerhans,
pubmed-meshheading:3535798-Male,
pubmed-meshheading:3535798-Middle Aged,
pubmed-meshheading:3535798-Neoplasm Proteins,
pubmed-meshheading:3535798-Neuropeptides,
pubmed-meshheading:3535798-Pancreatic Neoplasms
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pubmed:year |
1986
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pubmed:articleTitle |
A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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