|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1986-11-26
|
|
pubmed:abstractText |
The involvement of the lymphocyte function-associated antigen-1 (LFA-1) membrane molecule in cytolytic T lymphocyte (CTL) interactions with lymphoid target cells was investigated using CTL clones derived from two patients with a heritable deficiency of LFA-1. LFA-1 surface expression on the CTL clones was 1% of the normal level of LFA-1, unchanged with prolonged culture, and identical on 14 different CTL clones. The function of the LFA-1 molecule was addressed using the LFA-1-deficient CTL clones and LFA-1-deficient lymphoid target cells. The lytic activity of the LFA-1-deficient CTL clones was 43% of control when tested against a target cell line expressing normal levels of LFA-1 and less than 10% of control when tested against an LFA-1-deficient target cell line. These results demonstrate a direct involvement of LFA-1 in CTL-mediated cytolysis and suggest a more general dependence on LFA-1 in lymphoid cell-cell interactions.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-2423600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-3156928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-3511078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-3514236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-3517218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-3889159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-3898754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-3900204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-3900232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-6096477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-6193178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-6196430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-6201533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-6237120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-6345670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-6984191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3534001-714164
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0021-9738
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
78
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1387-91
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3534001-Antibodies, Monoclonal,
pubmed-meshheading:3534001-Antigens, Surface,
pubmed-meshheading:3534001-Cells, Cultured,
pubmed-meshheading:3534001-Clone Cells,
pubmed-meshheading:3534001-Culture Media,
pubmed-meshheading:3534001-Cytotoxicity, Immunologic,
pubmed-meshheading:3534001-Humans,
pubmed-meshheading:3534001-Interleukin-2,
pubmed-meshheading:3534001-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:3534001-T-Lymphocytes, Cytotoxic
|
|
pubmed:year |
1986
|
|
pubmed:articleTitle |
Abnormal cytolytic activity of lymphocyte function-associated antigen-1-deficient human cytolytic T lymphocyte clones.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
