Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1986-12-2
|
| pubmed:abstractText |
Eighty-three serum specimens from 24 patients infected with Candida albicans were examined for circulating Candida protein antigens with the Candida Detection System (CAND-TEC; Ramco Laboratories, Inc., Houston, Tex.). The medical records of each patient were reviewed for clinical evidence of Candida colonization or disease, predisposing factors for infection, underlying illness, the presence of a contaminated indwelling venous catheter, intravenous amphotericin B therapy, and outcome. Forty-nine serum specimens with antigen titers of 1:2 or less were obtained either from colonized patients or at a time when disseminated disease was not yet clinically suspected. Except for five specimens from two colonized patients, one with a contaminated arterial line, the other specimens with titers of 1:8 or greater (n = 14) were obtained from patients who had been clinically diagnosed and treated for disseminated candidiasis. Serum specimens with titers of 1:4 were often from patients with deep-seated candidal infection but were not uniformly diagnostic; in this situation additional specimens should be tested for Candida antigen titers. Only 1 of 24 serum specimens from patients with no evidence of C. albicans infection had a Candida protein antigen titer of 1:8. With a 1:8 or greater titer as a criterion for dissemination, the sensitivity of the CAND-TEC system was 71%, with a specificity of 98%. If the 1:8 titer for the colonized patient with a contaminated arterial line is not considered a false-positive result, the CAND-TEC sensitivity was 83%. The latex agglutination assay appears to be a useful, rapid, and noninvasive means of laboratory diagnosis of systemic candidiasis. The recovery of C. albicans from at least three body sites may also be a useful predictor of disseminated disease.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-352220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-374653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-5229422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-6377438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-6792913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-6833796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-6861734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-6999104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-7021699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-7192301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-868803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3533975-993329
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0095-1137
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
542-7
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading | |
| pubmed:year |
1986
|
| pubmed:articleTitle |
Candida detection system (CAND-TEC) to differentiate between Candida albicans colonization and disease.
|
| pubmed:publicationType |
Journal Article
|