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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1986-10-3
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pubmed:databankReference |
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pubmed:abstractText |
A human fetal liver cDNA library was screened at reduced hybridization stringency for v-raf-related sequences. In addition to the expected c-raf-1 cDNA, a second sequence was isolated. Comparison of the second gene (pks) to the other raf-related sequences revealed nucleotide homologies of 71%. The predicted amino acid sequence of the kinase domain is sufficiently similar to that of v-raf to suggest that pks may encode a polypeptide that exhibits serine/threonine kinase activity. The expression of pks mRNA (2.7 kilobases long) is elevated in peripheral blood mononuclear cells isolated from two patients with angioimmunoblastic lymphadenopathy with dysproteinemia, a disease in which autoantibodies are produced following the lymphoproliferative activation of B cells. Analysis of somatic cell hybrids for segregation of the pks locus revealed the presence of an additional locus closely related to the pks sequence.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-2424462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-2993863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-2997622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-3916923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-4831907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6095109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6169846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6254988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6319752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6320371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6321473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6324342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6325930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6328489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6351725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6431300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6438534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6590967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6601272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-6691137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-7071022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3529082-881736
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6312-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
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pubmed:year |
1986
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pubmed:articleTitle |
Pks, a raf-related sequence in humans.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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