Linked Life Data

3528344

Source:http://linkedlifedata.com/resource/pubmed/id/3528344

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-10-8
pubmed:abstractText
The nature of antigens shared between Mycobacterium leprae and other species of mycobacteria has been examined using a murine T-cell proliferation assay. Mice were immunized with different mycobacteria, and lymph node cultures were prepared one week later and challenged with M. leprae antigen. The 13 species of mycobacteria tested as antigens in this assay revealed that several species shared antigens in common with M. leprae as recognized by T-cell responses. C57BL/10J mice and congenic strains exhibit differences in T-cell responsiveness to M. leprae. B10.M and B10.Q mice are high responders and C57BL/10J are low responders, while F1 (C57BL/10J X B10.M) and (C57BL/10J X B10.Q) hybrid progeny are also low responders. These genetic differences were not observed when six other mycobacterial species were used as T-cell antigens. An unexpected finding was that the genetic pattern of T-cell responsiveness to M. marinum was identical to that observed for M. leprae using these strains of mice. Helper T cells may recognize antigenic determinants shared by M. leprae and M. marinum. These antigens may initiate the induction of T-cell responses to these two species of mycobacteria.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0148-916X
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
367-79
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Immunity to leprosy. IV. Murine T-cell proliferative responses to mycobacteria.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't