Linked Life Data

3527925

Source:http://linkedlifedata.com/resource/pubmed/id/3527925

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1986-10-21
pubmed:abstractText
Individual rabbit fetuses in utero were injected intramuscularly with either 2.0 Units protamine zinc insulin or saline at 23 days gestation after surgical reduction of litter size to 4 fetuses at 9 days gestation. Insulin-treated fetuses were still hyperinsulinaemic compared with littermate controls at 28 days gestation. Neither fetal body weight nor carcase composition were affected by insulin injection, but placental weight and RNA content were increased. Placental weight was highly correlated with plasma insulin concentration in control fetuses, but not in insulin-injected fetuses. Twenty-four hours after injection of insulin into individual fetal rabbits from normal litters at 23 or 27 days gestation insulin-injected fetuses were hyperinsulinaemic and euglycaemic, but had significantly higher plasma glucocorticoid concentrations than saline-injected littermates. Stimulation of placental growth by fetal insulin may be an important component of the fetal growth stimulatory effect of endogenous insulin. Growth stimulatory effects of exogenous insulin may be antagonised by raised plasma glucocorticoid concentrations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0018-5043
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
441-5
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Increased placental growth and raised plasma glucocorticoid concentrations in fetal rabbits injected with insulin in utero.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't