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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1986-9-25
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pubmed:abstractText |
Combinations of aztreonam/vancomycin, aztreonam/vancomycin/amikacin, and moxalactam/ticarcillin were compared in a prospective randomized trial as empiric therapy for febrile neutropenic cancer patients. Vancomycin was added to aztreonam to provide coverage against gram-positive organisms. Of 535 febrile episodes included in the study, 455 were evaluable. The aztreonam/vancomycin and aztreonam/vancomycin/amikacin combinations were both more effective than the moxalactam/ticarcillin combination in a total of 244 episodes of documented infection. The difference was due to the fact that both aztreonam-containing combinations were more effective than the moxalactam/ticarcillin combination in documented gram-positive infections. The three regimens were equally effective in 67 documented infections due to a single gram-negative bacterial species. (The response rates were 87, 86 and 94 percent for the aztreonam/vancomycin, aztreonam/vancomycin/amikacin, and moxalactam/ticarcillin combinations, respectively.) Aztreonam was effective as the single active antibiotic in the treatment of gram-negative infections in neutropenic patients; however, it must be used in combination with another antibiotic to provide gram-positive coverage.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0002-9343
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
243-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3526885-Adolescent,
pubmed-meshheading:3526885-Adult,
pubmed-meshheading:3526885-Aged,
pubmed-meshheading:3526885-Agranulocytosis,
pubmed-meshheading:3526885-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:3526885-Aztreonam,
pubmed-meshheading:3526885-Bacterial Infections,
pubmed-meshheading:3526885-Clinical Trials as Topic,
pubmed-meshheading:3526885-Drug Evaluation,
pubmed-meshheading:3526885-Female,
pubmed-meshheading:3526885-Gram-Negative Bacteria,
pubmed-meshheading:3526885-Humans,
pubmed-meshheading:3526885-Male,
pubmed-meshheading:3526885-Middle Aged,
pubmed-meshheading:3526885-Neoplasms,
pubmed-meshheading:3526885-Neutropenia,
pubmed-meshheading:3526885-Random Allocation
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pubmed:year |
1986
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pubmed:articleTitle |
Aztreonam therapy in neutropenic patients with cancer.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|