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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
1979-7-28
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pubmed:abstractText |
Oxidation of 1-piperidinoantraquinone (1-PA) in microsomal fractions of rat liver was studied. The only product of complete oxidation of 1-PA--(N-antraquinone-1)-delta-aminovaleric acid-was identified using paper and thin-layer chromatography. The participation of cytochrome P-450 in oxidation of 1-PA was demonstrated by sharp inhibition, involving blowing of the microsomes with CO and treatment with sodium deoxycholate. Studies of differential spectra of cytochrome P-450 in the presence of 1-PA are indicative of the first type of binding between 1-PA and cytochrome P-450. The binding constants (Ks) and the kinetic parameters (Km and V) for the above substrate in control microsomes and in those induced by phenobarbital and 3-methyl cholanthrene were determined. The results obtained suggest that cytochrome P-450 is involved in oxidation of a number of heterocyclic compounds resulting in the opening of the ring.
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pubmed:language |
rus
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0320-9725
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
634-9
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pubmed:dateRevised |
2007-7-23
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pubmed:meshHeading |
pubmed-meshheading:35249-Animals,
pubmed-meshheading:35249-Anthraquinones,
pubmed-meshheading:35249-Carbon Monoxide,
pubmed-meshheading:35249-Catalysis,
pubmed-meshheading:35249-Cytochrome P-450 Enzyme System,
pubmed-meshheading:35249-Deoxycholic Acid,
pubmed-meshheading:35249-Methylcholanthrene,
pubmed-meshheading:35249-Microsomes, Liver,
pubmed-meshheading:35249-NAD,
pubmed-meshheading:35249-NADP,
pubmed-meshheading:35249-Oxidation-Reduction,
pubmed-meshheading:35249-Phenobarbital,
pubmed-meshheading:35249-Piperidines,
pubmed-meshheading:35249-Rats,
pubmed-meshheading:35249-Spectrum Analysis
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pubmed:year |
1979
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pubmed:articleTitle |
[Cytochrome P-450 catalyzed oxidation of 1-piperidinoanthraquinone].
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
English Abstract
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