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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1978-9-29
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pubmed:abstractText |
1 Isolated rings of hamster aorta produced an unstable substance which inhibited platelet aggregation in vitro and had the same characteristics as prostacyclin. 2 Prostacyclin inhibited adenosine diphosphate (ADP)-induced aggregation of hamster platelets in vitro. 3 The effects of prostacyclin on ADP-induced platelet thrombi in the microcirculation of the hamster cheek pouch were studied with a television microscope. 4 Prostacyclin caused a dose-dependent increase in the time of iontophoretic application of ADP which was required to induce platelet thrombi formation and embolization in venules (30 to 40 micron diameter). 5 Prostacyclin caused a dose-dependent reduction in the total time during which ADP-induced thrombi were observed following local electrical damage to arterioles (40 to 80 micron diameter). 6 Thrombus formation in venules and arterioles was abolished by 500 ng/ml prostacyclin in the Krebs solution superfusing the hamster cheek pouch. 7 Prostacyclin was approximately twenty times more potent than prostaglandin E1 in preventing thrombus formation in the microcirculation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-1059088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-12538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-13871375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-334306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-344856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-4439372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-4521806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-5046152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-5448995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-599432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-6023964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-63657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-802670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-824686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-864112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-912187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/352466-934294
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
535-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:352466-Animals,
pubmed-meshheading:352466-Arterioles,
pubmed-meshheading:352466-Blood Flow Velocity,
pubmed-meshheading:352466-Cheek,
pubmed-meshheading:352466-Cricetinae,
pubmed-meshheading:352466-Epoprostenol,
pubmed-meshheading:352466-Male,
pubmed-meshheading:352466-Mesocricetus,
pubmed-meshheading:352466-Platelet Aggregation,
pubmed-meshheading:352466-Prostaglandins,
pubmed-meshheading:352466-Regional Blood Flow,
pubmed-meshheading:352466-Venules
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pubmed:year |
1978
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pubmed:articleTitle |
Prostacyclin (PGI2) inhibits the formation of platelet thrombi in arterioles and venules of the hamster cheek pouch.
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pubmed:publicationType |
Journal Article,
In Vitro
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