| pubmed-article:3521258 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3521258 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:3521258 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:3521258 | lifeskim:mentions | umls-concept:C0035629 | lld:lifeskim |
| pubmed-article:3521258 | lifeskim:mentions | umls-concept:C0199176 | lld:lifeskim |
| pubmed-article:3521258 | lifeskim:mentions | umls-concept:C1280519 | lld:lifeskim |
| pubmed-article:3521258 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:3521258 | pubmed:dateCreated | 1986-7-21 | lld:pubmed |
| pubmed-article:3521258 | pubmed:abstractText | With recent studies suggesting that children are the main introducers of influenza infections into families, we conducted a placebo-controlled, double-blind, randomized trial to study the prophylactic effectiveness of rimantadine hydrochloride in children on the transmission of influenza A infections within families. One hundred forty-five volunteers from 35 families completed this study during a naturally occurring outbreak of influenza A (H1N1) infection. Influenza infections, defined as a positive viral throat culture or a fourfold increase in antibody titer, occurred in 31.7% of children in the placebo group and 2.9% of children in the rimantadine group. Clinical illness with laboratory evidence of influenza infection occurred in 17.0% of children in the placebo group and 0% of children in the rimantadine group. Rimantadine was well tolerated by the children, with no significant difference in reported side effects between the placebo and rimantadine groups. Influenza A infection occurred in 19.0% of adults whose children were receiving a placebo and 8.8% of adults whose children were receiving rimantadine. On the basis of our study, rimantadine prophylaxis of children appears to be an effective method to prevent influenza A infection in children. Additional studies are needed to demonstrate the effects of rimantadine prophylaxis of children on the incidence of influenza A infection in their parents. | lld:pubmed |
| pubmed-article:3521258 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3521258 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3521258 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3521258 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3521258 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3521258 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3521258 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3521258 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3521258 | pubmed:issn | 0002-922X | lld:pubmed |
| pubmed-article:3521258 | pubmed:author | pubmed-author:CouchR BRB | lld:pubmed |
| pubmed-article:3521258 | pubmed:author | pubmed-author:CrawfordS ASA | lld:pubmed |
| pubmed-article:3521258 | pubmed:author | pubmed-author:GlezenW PWP | lld:pubmed |
| pubmed-article:3521258 | pubmed:author | pubmed-author:RamseyC NCNJr | lld:pubmed |
| pubmed-article:3521258 | pubmed:author | pubmed-author:CloverR DRD | lld:pubmed |
| pubmed-article:3521258 | pubmed:author | pubmed-author:AbellT DTD | lld:pubmed |
| pubmed-article:3521258 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3521258 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:3521258 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3521258 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3521258 | pubmed:pagination | 706-9 | lld:pubmed |
| pubmed-article:3521258 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:3521258 | pubmed:meshHeading | pubmed-meshheading:3521258-... | lld:pubmed |
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| pubmed-article:3521258 | pubmed:meshHeading | pubmed-meshheading:3521258-... | lld:pubmed |
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| pubmed-article:3521258 | pubmed:meshHeading | pubmed-meshheading:3521258-... | lld:pubmed |
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| pubmed-article:3521258 | pubmed:meshHeading | pubmed-meshheading:3521258-... | lld:pubmed |
| pubmed-article:3521258 | pubmed:meshHeading | pubmed-meshheading:3521258-... | lld:pubmed |
| pubmed-article:3521258 | pubmed:meshHeading | pubmed-meshheading:3521258-... | lld:pubmed |
| pubmed-article:3521258 | pubmed:meshHeading | pubmed-meshheading:3521258-... | lld:pubmed |
| pubmed-article:3521258 | pubmed:meshHeading | pubmed-meshheading:3521258-... | lld:pubmed |
| pubmed-article:3521258 | pubmed:meshHeading | pubmed-meshheading:3521258-... | lld:pubmed |
| pubmed-article:3521258 | pubmed:meshHeading | pubmed-meshheading:3521258-... | lld:pubmed |
| pubmed-article:3521258 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3521258 | pubmed:articleTitle | Effectiveness of rimantadine prophylaxis of children within families. | lld:pubmed |
| pubmed-article:3521258 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3521258 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:3521258 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3521258 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3521258 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3521258 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3521258 | lld:pubmed |
