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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1986-7-21
|
| pubmed:abstractText |
With recent studies suggesting that children are the main introducers of influenza infections into families, we conducted a placebo-controlled, double-blind, randomized trial to study the prophylactic effectiveness of rimantadine hydrochloride in children on the transmission of influenza A infections within families. One hundred forty-five volunteers from 35 families completed this study during a naturally occurring outbreak of influenza A (H1N1) infection. Influenza infections, defined as a positive viral throat culture or a fourfold increase in antibody titer, occurred in 31.7% of children in the placebo group and 2.9% of children in the rimantadine group. Clinical illness with laboratory evidence of influenza infection occurred in 17.0% of children in the placebo group and 0% of children in the rimantadine group. Rimantadine was well tolerated by the children, with no significant difference in reported side effects between the placebo and rimantadine groups. Influenza A infection occurred in 19.0% of adults whose children were receiving a placebo and 8.8% of adults whose children were receiving rimantadine. On the basis of our study, rimantadine prophylaxis of children appears to be an effective method to prevent influenza A infection in children. Additional studies are needed to demonstrate the effects of rimantadine prophylaxis of children on the incidence of influenza A infection in their parents.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0002-922X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
140
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
706-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3521258-Adamantane,
pubmed-meshheading:3521258-Adolescent,
pubmed-meshheading:3521258-Adult,
pubmed-meshheading:3521258-Child,
pubmed-meshheading:3521258-Child, Preschool,
pubmed-meshheading:3521258-Clinical Trials as Topic,
pubmed-meshheading:3521258-Double-Blind Method,
pubmed-meshheading:3521258-Female,
pubmed-meshheading:3521258-Humans,
pubmed-meshheading:3521258-Infant,
pubmed-meshheading:3521258-Influenza, Human,
pubmed-meshheading:3521258-Influenza A virus,
pubmed-meshheading:3521258-Influenza B virus,
pubmed-meshheading:3521258-Male,
pubmed-meshheading:3521258-Office Visits,
pubmed-meshheading:3521258-Patient Compliance,
pubmed-meshheading:3521258-Random Allocation,
pubmed-meshheading:3521258-Rimantadine
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Effectiveness of rimantadine prophylaxis of children within families.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
|