Linked Life Data

3521170

Source:http://linkedlifedata.com/resource/pubmed/id/3521170

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-7-1
pubmed:abstractText
Adult respiratory distress syndrome (ARDS) is a common and serious complication of septic shock. Pulmonary trapping of platelets (PPT) and leukocytes, and release of vasoactive and toxic substances such as prostaglandins, lysozymes and oxygen-radicals have been implicated as mediators of the lung injury. beta-Endorphin is regarded as one of the substances released during shock, and has been shown to cause cell damage similar to that seen with endotoxin, and also PPT. We recently reported that combined treatment with methylprednisolone, ibuprofen and naloxone significantly increased lasting survival in an LD100 canine endotoxin shock model. In the present study the effects of these drugs in various combinations were evaluated as regards blood pressure, hematocrit, peripheral platelet and leukocyte counts, intestinal damage and PPT in the same model. The effects of combined treatment were significantly decreased PPT, rise in blood pressure and abolition of bloody diarrhea. We concluded that ibuprofen and naloxone have additive action and that methylprednisolone has no effect on PPT.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0001-5482
pubmed:author
pubmed:issnType
Print
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Pulmonary platelet trapping in Escherichia coli endotoxin-injected dogs treated with methylprednisolone, ibuprofen and naloxone.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.