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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1986-6-27
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pubmed:abstractText |
A murine monoclonal antibody (ECS-1) was prepared from BALB/c mice immunized with trypsinized cultured human foreskin keratinocytes. The antibody showed a pattern suggestive of intercellular staining on the nucleated layers of normal human epidermis, adult palm, mouse lip epidermis, and cultured human keratinocytes. ECS-1 stained human fetal skin by 9 weeks estimated gestational age. ECS-1 reacted with a 35 kD protein extracted from neonatal foreskin epidermis and cultured human keratinocytes. The protein required Nonidet P-40 or sodium dodecyl sulfate and mercaptoethanol for solubilization. ECS-1 induced epidermal cell detachment which was enhanced by complement. ECS-1 shares characteristics with human pemphigus antibodies.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-202X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
634-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3519785-Animals,
pubmed-meshheading:3519785-Antibodies, Monoclonal,
pubmed-meshheading:3519785-Epidermal Growth Factor,
pubmed-meshheading:3519785-Female,
pubmed-meshheading:3519785-Fluorescent Antibody Technique,
pubmed-meshheading:3519785-Humans,
pubmed-meshheading:3519785-Mice,
pubmed-meshheading:3519785-Mice, Inbred BALB C,
pubmed-meshheading:3519785-Pemphigus
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pubmed:year |
1986
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pubmed:articleTitle |
Monoclonal antibody to a 35 kD epidermal protein induces cell detachment.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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