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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1986-6-27
|
| pubmed:abstractText |
Routinely fixed and processed gingival biopsies from childhood gingivitis, juvenile periodontitis and chronic adult periodontitis patients have been stained immunocytochemically with a monoclonal anti HLADr antibody to aid in the identification and quantification of cell types in the inflammatory infiltrates. Using immunoperoxidase staining and morphological criteria, 9 cell types were quantified in 30 patients. Lesions in the 3 groups were found to differ widely both in size and composition. In the small childhood gingivitis lesions, most cells were small lymphocytes, over half of which were HLADr positive, whereas in juvenile periodontitis biopsies, well over half the infiltrate was plasma cells. The chronic adult periodontitis samples showed greater variability in composition between these 2 extremes, perhaps reflecting differences in disease activity. These results suggest that, when disease is quiescent, the volume of inflamed gingival connective tissue is small and is dominated by B-small lymphocytes, whilst on activation, the lesion increases in size and much of the B-lymphocyte population is transformed to plasma cells. This view corroborates the results of other workers with regard to juvenile periodontitis, but suggests a different interpretation of the quiescent lesion of childhood gingivitis from that current in the literature.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0303-6979
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
281-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3519691-Adult,
pubmed-meshheading:3519691-Aggressive Periodontitis,
pubmed-meshheading:3519691-Antibodies, Monoclonal,
pubmed-meshheading:3519691-Cell Count,
pubmed-meshheading:3519691-Chronic Disease,
pubmed-meshheading:3519691-Gingivitis,
pubmed-meshheading:3519691-HLA-DR Antigens,
pubmed-meshheading:3519691-Histocompatibility Antigens Class II,
pubmed-meshheading:3519691-Histocytochemistry,
pubmed-meshheading:3519691-Humans,
pubmed-meshheading:3519691-Immunoenzyme Techniques,
pubmed-meshheading:3519691-Leukocyte Count,
pubmed-meshheading:3519691-Leukocytes,
pubmed-meshheading:3519691-Lymphocytes,
pubmed-meshheading:3519691-Macrophages,
pubmed-meshheading:3519691-Monocytes,
pubmed-meshheading:3519691-Periodontal Diseases,
pubmed-meshheading:3519691-Periodontitis,
pubmed-meshheading:3519691-Plasma Cells
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
The nature of the inflammatory infiltrates in childhood gingivitis, juvenile periodontitis and adult periodontitis: immunocytochemical studies using a monoclonal antibody to HLADr.
|
| pubmed:publicationType |
Journal Article
|