Linked Life Data

3514464

Source:http://linkedlifedata.com/resource/pubmed/id/3514464

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-5-1
pubmed:abstractText
After a sublethal exposure to lipopolysaccharide (LPS) or to lipid A, which is that portion of the LPS molecule associated with endotoxicity, a transient period ensues during which a normally responsive individual is rendered hyporesponsive to LPS-induced toxicity. This period has been defined as early-phase endotoxin tolerance. Recently, a nontoxic derivative of lipid A from Salmonella typhimurium, monophosphoryl lipid A (MPL), was isolated and purified. In this study, we assessed the ability of MPL to induce early endotoxin tolerance. Initial injection of MPL resulted in a dose-dependent stimulation of both serum colony-stimulating factor and serum interferon, indicators of in vivo LPS responsiveness. In contrast, MPL failed to induce the symptoms of endotoxicity which are normally seen after injection of even sublethal amounts of intact endotoxin or lipid A preparations. Injection of MPL on day 0 reduced significantly the amount of LPS-induced serum colony-stimulating factor and interferon produced upon challenge with Escherichia coli LPS 3 days later and also mitigated toxic manifestations, as evidenced by a marked increase in the 50% lethal dose. Like the early tolerance induced by wild-type (toxic) LPS, MPL-induced tolerance was characterized by an accompanying elevation in the number of bone marrow-derived macrophage progenitor cells and by an alteration in bone marrow cell sizing profiles. These results indicate that MPL is effective in inducing a state of LPS-hyporesponsiveness without the toxic side effects of endotoxin and that the structural component(s) necessary for induction of early-phase endotoxin tolerance is contained within MPL.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-3905964, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-411630, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-4867999, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-4936184, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-4956238, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-513059, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-6163873, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-6183219, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-6378795, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-6382555, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-6474003, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-6602767, http://linkedlifedata.com/resource/pubmed/commentcorrection/3514464-6749846
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-11
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Early-phase endotoxin tolerance: induction by a detoxified lipid A derivative, monophosphoryl lipid A.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.