Linked Life Data

3514067

Source:http://linkedlifedata.com/resource/pubmed/id/3514067

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-5-12
pubmed:abstractText
Studies of the in vivo insulin action in conventionally treated Type 1 diabetic patients have shown insulin resistance, especially in poorly controlled patients. We reported previously on impaired basal and insulin-stimulated glucose utilization in adipocytes from Type 1 diabetic subjects. In this study we have examined whether a near-normalization of glycaemia and plasma levels of metabolites in Type 1 diabetic patients induced by continuous subcutaneous insulin infusion might reverse abnormalities of adipose tissue metabolism. 11 Type 1 diabetic subjects who had been treated conventionally with diet and insulin for 11 yr were studied before and after continuous subcutaneous insulin infusion for 6 months. In Type 1 diabetic patients before insulin pump treatment we found decreased adipocyte insulin binding (p less than 0.01), normal insulin binding to monocytes and erythrocytes, impaired insulin sensitivity of the adipocyte glucose transport (p = 0.02) and reduced basal and maximally insulin-stimulated rates of adipocyte glucose oxidation and lipogenesis (all p less than 0.05). After pump therapy for 6 months we found a further reduction of basal and maximal adipocyte glucose oxidation and lipogenesis (all p less than or equal to 0.05), whereas we found no significant changes of insulin receptor binding or insulin sensitivity of adipocyte glucose utilization. We conclude that continuous subcutaneous insulin infusion of Type 1 diabetic patients for 6 months aggravates the defects in basal (non-insulin-stimulated) and maximally insulin-stimulated glucose utilization of isolated adipocytes despite an optimization of glycaemic control and a near-normalization of plasma metabolites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0265-5985
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-23
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:3514067-Adipose Tissue, pubmed-meshheading:3514067-Adult, pubmed-meshheading:3514067-Biological Transport, pubmed-meshheading:3514067-Blood Glucose, pubmed-meshheading:3514067-Diabetes Mellitus, Type 1, pubmed-meshheading:3514067-Erythrocytes, pubmed-meshheading:3514067-Fasting, pubmed-meshheading:3514067-Fatty Acids, Nonesterified, pubmed-meshheading:3514067-Female, pubmed-meshheading:3514067-Glucose, pubmed-meshheading:3514067-Growth Hormone, pubmed-meshheading:3514067-Humans, pubmed-meshheading:3514067-Hydrocortisone, pubmed-meshheading:3514067-Insulin, pubmed-meshheading:3514067-Insulin Infusion Systems, pubmed-meshheading:3514067-Ketone Bodies, pubmed-meshheading:3514067-Lactates, pubmed-meshheading:3514067-Lactic Acid, pubmed-meshheading:3514067-Male, pubmed-meshheading:3514067-Receptor, Insulin
pubmed:year
1986
pubmed:articleTitle
Continuous subcutaneous insulin infusion fails to correct impaired basal glucose metabolism and impaired insulin sensitivity of adipocytes from patients with type 1 (insulin-dependent) diabetes.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't