| pubmed-article:3513183 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3513183 | lifeskim:mentions | umls-concept:C0016720 | lld:lifeskim |
| pubmed-article:3513183 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:3513183 | lifeskim:mentions | umls-concept:C1513528 | lld:lifeskim |
| pubmed-article:3513183 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:3513183 | lifeskim:mentions | umls-concept:C0085224 | lld:lifeskim |
| pubmed-article:3513183 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:3513183 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:3513183 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:3513183 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:3513183 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3513183 | pubmed:dateCreated | 1986-4-24 | lld:pubmed |
| pubmed-article:3513183 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3513183 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3513183 | pubmed:abstractText | We have investigated the molecular basis for a 25- to 30-fold overexpression of the c-Ki-ras oncogene in a mouse bone marrow-derived, early myeloid cell line, 416B. Southern blot hybridizations revealed that the 416B cells contain a rearranged c-Ki-ras gene in addition to an apparently normal gene. Molecular cloning and DNA sequence analyses demonstrated that the rearrangement involves the insertion of a 3.5-kilobase-pair segment of Friend virus that includes the envelope gene (env) and 3' long terminal repeat. The Friend provirus is positioned between a 5' nontranslated exon (exon phi) and the first coding exon (exon 1) of the c-Ki-ras gene in the same transcriptional orientation. Results of RNA blot analyses indicate that transcription from the rearranged gene initiates at a promoter that excludes sequences in exon phi. The data support the hypothesis that enhanced c-Ki-ras expression in the 416B cells results from integration of a Friend provirus within this gene. | lld:pubmed |
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| pubmed-article:3513183 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3513183 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3513183 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3513183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3513183 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3513183 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3513183 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3513183 | pubmed:author | pubmed-author:GlickBB | lld:pubmed |
| pubmed-article:3513183 | pubmed:author | pubmed-author:GeorgeD LDL | lld:pubmed |
| pubmed-article:3513183 | pubmed:author | pubmed-author:FreemanNN | lld:pubmed |
| pubmed-article:3513183 | pubmed:author | pubmed-author:TruskoSS | lld:pubmed |
| pubmed-article:3513183 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3513183 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:3513183 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3513183 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3513183 | pubmed:pagination | 1651-5 | lld:pubmed |
| pubmed-article:3513183 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3513183 | pubmed:meshHeading | pubmed-meshheading:3513183-... | lld:pubmed |
| pubmed-article:3513183 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3513183 | pubmed:articleTitle | Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line. | lld:pubmed |
| pubmed-article:3513183 | pubmed:publicationType | Journal Article | lld:pubmed |
