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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1986-4-10
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pubmed:databankReference |
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pubmed:abstractText |
A partial cDNA clone for the B-26 region of apolipoprotein B was isolated from an adult human liver DNA library by screening with an oligonucleotide probe derived from amino-terminal protein sequence obtained from purified B-26 peptide. Antisera against a synthetic 17-residue peptide whose amino acid sequence was encoded by the clone cross-reacts with apolipoproteins B-26, B-100, and B-48, but not with B-74. The nucleotide sequence immediately upstream from the amino terminus of B-26 codes for an apparent signal sequence, implying that the B-26 moiety is in an amino-terminal locus in the B-100 protein. That this sequence represents a 5' end region is further supported by primer extension analysis using a fragment of the cDNA clone and by S1 nuclease protection experiments using the corresponding region in a genomic clone.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-210450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-216702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-218611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-265521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-3847440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-3860811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-3860836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-3919393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-3986194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-4368566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-5963888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6183259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6207999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6243777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6272870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6274388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6373369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6379599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6547210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6564130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6694911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6855596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-6930644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-7126555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-7161558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-7174693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3513177-728996
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1467-71
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3513177-Amino Acid Sequence,
pubmed-meshheading:3513177-Apolipoproteins B,
pubmed-meshheading:3513177-Base Sequence,
pubmed-meshheading:3513177-Chromosome Mapping,
pubmed-meshheading:3513177-Cloning, Molecular,
pubmed-meshheading:3513177-DNA,
pubmed-meshheading:3513177-Genes,
pubmed-meshheading:3513177-Humans,
pubmed-meshheading:3513177-Immunosorbent Techniques,
pubmed-meshheading:3513177-RNA, Messenger
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pubmed:year |
1986
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pubmed:articleTitle |
Isolation of a cDNA clone encoding the amino-terminal region of human apolipoprotein B.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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