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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1986-2-5
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pubmed:abstractText |
Acute otitis media is the most common bacterial infection of childhood. The effectiveness of oral antihistamine-decongestant mixtures in the treatment of this illness remains controversial in clinical practice. In a double-blind randomized study, 82 children (aged under 15 years) with acute otitis media were treated with amoxicillin and either a decongestant-antihistamine mixture (Dimetapp) or placebo. All diagnoses required agreement between a family practice resident and the supervising family physician. Clinical course was assessed by symptom diaries completed by parents and by follow-up examination at approximately two weeks, which included pneumatic otoscopy. No statistically significant benefit of the antihistamine-decongestant mixture was shown in terms of resolution of the symptoms or prevention of the complications of acute otitis media. It is recommended that antihistamine-decongestants not be routinely added to an antibiotic in the treatment of acute otitis media in children.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0094-3509
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-43
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:3510268-Adolescent,
pubmed-meshheading:3510268-Amoxicillin,
pubmed-meshheading:3510268-Brompheniramine,
pubmed-meshheading:3510268-Child,
pubmed-meshheading:3510268-Child, Preschool,
pubmed-meshheading:3510268-Clinical Trials as Topic,
pubmed-meshheading:3510268-Double-Blind Method,
pubmed-meshheading:3510268-Drug Combinations,
pubmed-meshheading:3510268-Drug Evaluation,
pubmed-meshheading:3510268-Female,
pubmed-meshheading:3510268-Humans,
pubmed-meshheading:3510268-Infant,
pubmed-meshheading:3510268-Male,
pubmed-meshheading:3510268-Otitis Media,
pubmed-meshheading:3510268-Phenylephrine,
pubmed-meshheading:3510268-Phenylpropanolamine,
pubmed-meshheading:3510268-Pseudoephedrine,
pubmed-meshheading:3510268-Pyridines,
pubmed-meshheading:3510268-Random Allocation,
pubmed-meshheading:3510268-Sex Factors
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pubmed:year |
1986
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pubmed:articleTitle |
Are antihistamine-decongestants of value in the treatment of acute otitis media in children?
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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