Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-3-23
pubmed:abstractText
Nine pleomorphic adenomas of the human parotid gland were investigated. Within this series the group of cases having clonal aberrations of chromosome Nr 8 predominates. The occurrence of cases with trisomy-8 and cases with structural rearrangements involving a breakpoint in 8q11-8q13 allows a further subdivision of this group of tumors. Our special interest in this paper is devoted to the latter group. The hypothesis is proposed that in these cases the chromosomal rearrangement is the primary event in tumorigenesis, leading to activation of a so far unknown oncogene located most likely at 8q12. The translocations to different recipient chromosomes may serve as sign posts to transcriptionally active chromosomal domains in the salivary gland.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0016-6707
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Structural rearrangements of chromosome Nr 8 involving 8q12--a primary event in pleomorphic ademona of the parotid gland.
pubmed:affiliation
Centre of Human Genetics and Genetic Counseling, University of Bremen, FRG.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't