| pubmed-article:3505764 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3505764 | lifeskim:mentions | umls-concept:C0034526 | lld:lifeskim |
| pubmed-article:3505764 | lifeskim:mentions | umls-concept:C0029431 | lld:lifeskim |
| pubmed-article:3505764 | lifeskim:mentions | umls-concept:C0034525 | lld:lifeskim |
| pubmed-article:3505764 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:3505764 | lifeskim:mentions | umls-concept:C0439852 | lld:lifeskim |
| pubmed-article:3505764 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:3505764 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:3505764 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:3505764 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:3505764 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3505764 | pubmed:dateCreated | 1989-3-22 | lld:pubmed |
| pubmed-article:3505764 | pubmed:abstractText | An in vitro co-culture system was applied to study the direct and indirect effects of irradiation on osteoclast formation. Osteoclast precursor-free fetal mouse metatarsal bones were employed as osteoclast-forming inductor and periostea dissected from fetal calvaria as source of proliferating progenitor cells. Direct radiation effects on the formation of osteoclasts were assessed in co-cultures of irradiated periostea and non-irradiated bone rudiments. The results showed that the (blood-borne) periosteal progenitors were rather radiosensitive. A radiation 'survival' curve of osteoclast formation in relation to various doses could be constructed yielding a mean lethal dose (Do value) of 0.94 +/- 0.02 Gy and an extrapolation number of 1.67 +/- 0.01. Irradiation of the fetal long bones by low doses, effective for direct elimination of osteoclast progenitor cells, did not indirectly affect osteoclast development from the non-irradiated periosteal progenitor population. However, at relatively high radiation levels, though not lethal for the long bone rudiments, a significant inhibition of osteoclast formation became evident. The results indicate that radiation primarily affects osteoclast formation via a direct action on radiosensitive, proliferating progenitor cells. Injury to long bone models by relatively high radiation doses may also lead to severe disturbance of osteoclast formation kinetics. | lld:pubmed |
| pubmed-article:3505764 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3505764 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3505764 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3505764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3505764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3505764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3505764 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3505764 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3505764 | pubmed:issn | 0169-6009 | lld:pubmed |
| pubmed-article:3505764 | pubmed:author | pubmed-author:NijweideP JPJ | lld:pubmed |
| pubmed-article:3505764 | pubmed:author | pubmed-author:SchevenB ABA | lld:pubmed |
| pubmed-article:3505764 | pubmed:author | pubmed-author:Kawilarang-de... | lld:pubmed |
| pubmed-article:3505764 | pubmed:author | pubmed-author:WassenaarA... | lld:pubmed |
| pubmed-article:3505764 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3505764 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:3505764 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3505764 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3505764 | pubmed:pagination | 291-300 | lld:pubmed |
| pubmed-article:3505764 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3505764 | pubmed:meshHeading | pubmed-meshheading:3505764-... | lld:pubmed |
| pubmed-article:3505764 | pubmed:meshHeading | pubmed-meshheading:3505764-... | lld:pubmed |
| pubmed-article:3505764 | pubmed:meshHeading | pubmed-meshheading:3505764-... | lld:pubmed |
| pubmed-article:3505764 | pubmed:meshHeading | pubmed-meshheading:3505764-... | lld:pubmed |
| pubmed-article:3505764 | pubmed:meshHeading | pubmed-meshheading:3505764-... | lld:pubmed |
| pubmed-article:3505764 | pubmed:meshHeading | pubmed-meshheading:3505764-... | lld:pubmed |
| pubmed-article:3505764 | pubmed:meshHeading | pubmed-meshheading:3505764-... | lld:pubmed |
| pubmed-article:3505764 | pubmed:meshHeading | pubmed-meshheading:3505764-... | lld:pubmed |
| pubmed-article:3505764 | pubmed:meshHeading | pubmed-meshheading:3505764-... | lld:pubmed |
| pubmed-article:3505764 | pubmed:meshHeading | pubmed-meshheading:3505764-... | lld:pubmed |
| pubmed-article:3505764 | pubmed:meshHeading | pubmed-meshheading:3505764-... | lld:pubmed |
| pubmed-article:3505764 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3505764 | pubmed:articleTitle | Direct and indirect radiation effects on osteoclast formation in vitro. | lld:pubmed |
| pubmed-article:3505764 | pubmed:affiliation | Laboratory of Cell Biology and Histology, University of Leiden, The Netherlands. | lld:pubmed |
| pubmed-article:3505764 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3505764 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
