| pubmed-article:350384 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:350384 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:350384 | lifeskim:mentions | umls-concept:C0194037 | lld:lifeskim |
| pubmed-article:350384 | lifeskim:mentions | umls-concept:C0023972 | lld:lifeskim |
| pubmed-article:350384 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:350384 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:350384 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:350384 | pubmed:dateCreated | 1978-8-14 | lld:pubmed |
| pubmed-article:350384 | pubmed:abstractText | Hematological and immunosuppressive effects of various single doses of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) were evaluated in the preclinical canine model. Immune function appeared not to be impaired by treatment with CCNU, but severe myelotoxicity contributed to the death of 3 of 4 dogs given 10 mg CCNU per kg and 5 of 5 dogs given 15 mg CCNU per kg within 10 days after drug administration. Infusions of autologous bone marrow protected 6 of 6 dogs receiving 15 mg CCNU per kg and 6 of 6 dogs receiving 20 mg CCNU per kg from lethal marrow failure. Dogs given 30 mg CCNU per kg and autologous marrow died within 7 days from severe gastrointestinal toxicity. We conclude that autologous bone marrow support may allow the use of high-dose CCNU regimens and thereby increase its therapeutic efficacy in the treatment of advanced cancer. | lld:pubmed |
| pubmed-article:350384 | pubmed:language | eng | lld:pubmed |
| pubmed-article:350384 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:350384 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:350384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:350384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:350384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:350384 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:350384 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:350384 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:350384 | pubmed:author | pubmed-author:AbeOO | lld:pubmed |
| pubmed-article:350384 | pubmed:author | pubmed-author:ThierfelderSS | lld:pubmed |
| pubmed-article:350384 | pubmed:author | pubmed-author:NetzelBB | lld:pubmed |
| pubmed-article:350384 | pubmed:author | pubmed-author:RodtH VHV | lld:pubmed |
| pubmed-article:350384 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:350384 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:350384 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:350384 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:350384 | pubmed:pagination | 2157-9 | lld:pubmed |
| pubmed-article:350384 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:350384 | pubmed:meshHeading | pubmed-meshheading:350384-A... | lld:pubmed |
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| pubmed-article:350384 | pubmed:meshHeading | pubmed-meshheading:350384-B... | lld:pubmed |
| pubmed-article:350384 | pubmed:meshHeading | pubmed-meshheading:350384-B... | lld:pubmed |
| pubmed-article:350384 | pubmed:meshHeading | pubmed-meshheading:350384-S... | lld:pubmed |
| pubmed-article:350384 | pubmed:meshHeading | pubmed-meshheading:350384-B... | lld:pubmed |
| pubmed-article:350384 | pubmed:meshHeading | pubmed-meshheading:350384-M... | lld:pubmed |
| pubmed-article:350384 | pubmed:meshHeading | pubmed-meshheading:350384-T... | lld:pubmed |
| pubmed-article:350384 | pubmed:meshHeading | pubmed-meshheading:350384-T... | lld:pubmed |
| pubmed-article:350384 | pubmed:meshHeading | pubmed-meshheading:350384-I... | lld:pubmed |
| pubmed-article:350384 | pubmed:meshHeading | pubmed-meshheading:350384-N... | lld:pubmed |
| pubmed-article:350384 | pubmed:meshHeading | pubmed-meshheading:350384-L... | lld:pubmed |
| pubmed-article:350384 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:350384 | pubmed:articleTitle | Autologous bone marrow grafts in dogs treated with lethal doses of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. | lld:pubmed |
| pubmed-article:350384 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:350384 | lld:pubmed |
