Linked Life Data

3501806

Source:http://linkedlifedata.com/resource/pubmed/id/3501806

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-3-29
pubmed:abstractText
Protective effects of rIL-2 modulation on immune tumoricidal activity (cytolytic activity as expressed in LU/spleen) as well as tumor mass was examined in a murine malignant tumor model. Using rIL-2 and Adriamycin both separately and concurrently to treat an established in vivo murine tumor, we demonstrate immune cytolytic function associated with drug treatment is rescued with pretreatment of IL-2 prior to administration of cytotoxic drug (i.e., to have greater tumoricidal activity as determined by lytic units/spleen than either rIL-2 or Adriamycin treatment alone). Reduction of tumor mass was observed whenever IL-2 was administered. A significant inflammatory response was observed in animals with drug and IL-2 pretreatment. This data suggests a more effective approach to the treatment of this tumor model is pretreatment of IL-2 prior to administration of chemotherapy versus either IL-2 or chemotherapy alone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0141-2760
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-3
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
An immunochemotherapy protocol for enhanced tumoricidal activity: in vivo treatment with IL-2 prior to chemotherapy.
pubmed:affiliation
Department of Medicine, Medical College of Georgia, Augusta 30912.
pubmed:publicationType
Journal Article