Linked Life Data

3501418

Source:http://linkedlifedata.com/resource/pubmed/id/3501418

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-2-29
pubmed:abstractText
We examined the suppressive effect of a newly developed antitumor agent, 15-deoxyspergualin (DSP), on the plaque-forming cell responses to various antigens. The intraperitoneal injections of DSP at a dose of 5.0 mg/kg body weight suppressed drastically the development of plaque-forming cells in the spleen of C57BL/6 mice immunized with sheep red blood cells (0.2 ml of a 5% suspension), trinitrophenyl-lipopolysaccharide (1 microgram/mice) and trinitrophenyl-Ficoll (100 micrograms/mice). These suppressive effects were observed when the administration of DSP was started after the injection of antigens. The responsiveness of spleen cells from DSP-treated mice was also checked in in vitro culture. Responsiveness to lipopolysaccharide in vitro was not reduced. Furthermore DSP did not significantly suppress the responsiveness of spleen cells to succinylated concanavalin A or production of interleukin-1 or -2. The results are discussed with regards to the mode of action of DSP on immune responsiveness.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0162-3109
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Immunosuppressive activities of deoxyspergualin. II. The effect on the antibody responses.
pubmed:affiliation
Laboratory of Immunology, Niigata University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't