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rdf:type |
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lifeskim:mentions |
umls-concept:C0003343,
umls-concept:C0004927,
umls-concept:C0032556,
umls-concept:C0086418,
umls-concept:C0205225,
umls-concept:C0439677,
umls-concept:C0444598,
umls-concept:C1510411,
umls-concept:C1517806,
umls-concept:C1533691,
umls-concept:C2323499,
umls-concept:C2348042
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pubmed:issue |
12
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pubmed:dateCreated |
1988-3-18
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pubmed:abstractText |
A retrovirus encoding polyoma middle T antigen has been used to infect a murine hemopoietic cell line (FDC-P1) dependent on either granulocyte-macrophage colony-stimulating factor (GM-CSF) or multipotential colony-stimulating factor (Multi-CSF). A number of cell lines have been established on the basis of their initial ability to proliferate in the absence of added colony-stimulating factor (CSF). The transformed lines display one of three patterns of growth in vitro: those able to grow fully autonomously; those whose proliferation depends on cell density; and those displaying dependence on added CSF regardless cell density. This latter class of cells are reminiscent of the majority of primary myeloid leukemic cells. Unlike parental FDC-P1 cells, all three classes of transformed cells are leukemogenic in syngeneic mice; moreover, they produce variable amounts of GM-CSF which we believe underlies their neoplastic behavior.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-2411538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-2426575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-2582236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-2987918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-2988782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-2988783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-300377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-3012562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-3027584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-3528176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-3878229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-6096003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-6265803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-6304524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-6325177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-6331674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-6434004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-6594688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-6678608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501372-6968334
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3703-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3501372-Animals,
pubmed-meshheading:3501372-Antigens, Polyomavirus Transforming,
pubmed-meshheading:3501372-Cell Line,
pubmed-meshheading:3501372-Cell Transformation, Neoplastic,
pubmed-meshheading:3501372-Cells, Cultured,
pubmed-meshheading:3501372-Female,
pubmed-meshheading:3501372-Hematopoietic Stem Cells,
pubmed-meshheading:3501372-Interleukin-3,
pubmed-meshheading:3501372-Male,
pubmed-meshheading:3501372-Mice,
pubmed-meshheading:3501372-Mice, Inbred C57BL,
pubmed-meshheading:3501372-Mice, Inbred DBA
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pubmed:year |
1987
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pubmed:articleTitle |
The in vitro behavior of hemopoietic cells transformed by polyoma middle T antigen parallels that of primary human myeloid leukemic cells.
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pubmed:affiliation |
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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