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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1987-12-28
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pubmed:abstractText |
Osteopontin is a 44 kd phosphoprotein abundant in bone matrix. We isolated a partial length cDNA for rat osteopontin and used it to examine its tissue specificity, its expression during bone development and its hormonal regulation. Osteopontin mRNA is most abundant in bone but is also found in considerable amounts in kidney. Osteopontin mRNA is regulated by the osteotropic hormones dexamethasone and 1,25(OH)2D3. Estimates of osteopontin mRNA levels indicate that the osteopontin gene is turned on relatively late in calvarial development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitriol,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Osteonectin,
http://linkedlifedata.com/resource/pubmed/chemical/Osteopontin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Spp1 protein, rat
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
148
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1129-36
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3500718-Age Factors,
pubmed-meshheading:3500718-Alkaline Phosphatase,
pubmed-meshheading:3500718-Animals,
pubmed-meshheading:3500718-Bone Development,
pubmed-meshheading:3500718-Bone Matrix,
pubmed-meshheading:3500718-Calcitriol,
pubmed-meshheading:3500718-Calcium-Binding Proteins,
pubmed-meshheading:3500718-Carrier Proteins,
pubmed-meshheading:3500718-Collagen,
pubmed-meshheading:3500718-Dexamethasone,
pubmed-meshheading:3500718-Gene Expression Regulation,
pubmed-meshheading:3500718-Kidney,
pubmed-meshheading:3500718-Osteoblasts,
pubmed-meshheading:3500718-Osteocalcin,
pubmed-meshheading:3500718-Osteonectin,
pubmed-meshheading:3500718-Osteopontin,
pubmed-meshheading:3500718-RNA, Messenger,
pubmed-meshheading:3500718-Rats,
pubmed-meshheading:3500718-Sialoglycoproteins,
pubmed-meshheading:3500718-Tissue Distribution
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pubmed:year |
1987
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pubmed:articleTitle |
Tissue specificity and developmental expression of rat osteopontin.
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pubmed:affiliation |
Department of Bone Biology and Osteoporosis Research, Merck Sharp and Dohme Research Laboratories, West Point, PA 19486.
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pubmed:publicationType |
Journal Article
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