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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1988-1-19
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pubmed:abstractText |
Twenty-five patients about to undergo cataract surgery and ten patients about to undergo vitrectomy received a 1-g intravenous dose of imipenem before surgery. Specimens of aqueous or vitreous humor were then obtained and assayed for antibiotic content with a microbiologic disk agar technique. A mean peak aqueous humor level of 2.99 micrograms/ml was found at approximately two hours after administration, and a mean vitreous level of 2.53 micrograms/ml was found from two hours to three hours 15 minutes after administration. These concentrations were well above the minimum inhibitory concentration of imipenem for 90% (MIC90) of Staphylococcus epidermidis, S. aureus, and the Enterobacteriaceae commonly involved in bacterial endophthalmitis.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0002-9394
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
104
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
649-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3500645-Aqueous Humor,
pubmed-meshheading:3500645-Endophthalmitis,
pubmed-meshheading:3500645-Humans,
pubmed-meshheading:3500645-Imipenem,
pubmed-meshheading:3500645-Nausea,
pubmed-meshheading:3500645-Osmolar Concentration,
pubmed-meshheading:3500645-Thienamycins,
pubmed-meshheading:3500645-Vitreous Body
|
pubmed:year |
1987
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pubmed:articleTitle |
Penetration of imipenem into human aqueous and vitreous humor.
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pubmed:affiliation |
Division of Infectious Diseases and Epidemiology, St. Luke's-Roosevelt Hospital Center, New York, New York 10025.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|