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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1988-1-6
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pubmed:abstractText |
Immunization of BALB/c mice with gp10/20, a glycoconjugate purified from Leishmania mexicana subsp. amazonensis, induced a delayed-type hypersensitivity response to the antigen, and a significant increase was elicited in the size of the lesion induced by a subcutaneous infection with this parasite. The increase in the lesion size was observed when mice were immunized by the subcutaneous and the intraperitoneal routes. The subcutaneous immunization with gp10/20 was unable to reverse the prophylactic effect of an intravenous injection of irradiated promastigotes. An L3T4+ T-cell line specific for gp10/20 was able to transfer this lesion-enhancing effect and specific delayed-type hypersensitivity reactivity to normal syngeneic recipients. The same T-cell line was a good producer of a hematopoietic growth factor, granulocyte-macrophage colony-stimulating factor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-15275612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-157979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-2416692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-2418115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-2425330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-3079902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-3160663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-3160786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-3488146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-3490440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-3862105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-3907906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-3926895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-3950420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-447442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-4558410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-6120976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-6194223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-6205088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-6354255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-6373932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-6420330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-6600767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-6604760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-6604879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-6691411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-6976781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-7220075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500131-88500
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3142-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3500131-Animals,
pubmed-meshheading:3500131-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:3500131-Antigens, Protozoan,
pubmed-meshheading:3500131-Bone Marrow Cells,
pubmed-meshheading:3500131-Glycoproteins,
pubmed-meshheading:3500131-Growth Substances,
pubmed-meshheading:3500131-Hypersensitivity, Delayed,
pubmed-meshheading:3500131-Immunity, Cellular,
pubmed-meshheading:3500131-Immunization,
pubmed-meshheading:3500131-Immunization, Passive,
pubmed-meshheading:3500131-Leishmania mexicana,
pubmed-meshheading:3500131-Leishmaniasis,
pubmed-meshheading:3500131-Mice,
pubmed-meshheading:3500131-T-Lymphocytes
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pubmed:year |
1987
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pubmed:articleTitle |
The cellular immune response to a purified antigen from Leishmania mexicana subsp. amazonensis enhances the size of the leishmanial lesion on susceptible mice.
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pubmed:affiliation |
Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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