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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1978-7-15
|
pubmed:abstractText |
I.C.I. 35868 is a promising new intravenous induction agent, but intravenous injection of the initial 2% formulation frequently caused pain. The solvent vehicle of the 2% formulation, which contained Cremophor E.L. and ethanol, was therefore investigated to see if this could be the cause of the pain. Twenty volunteers received both 5 ml isotonic saline and 5 ml solvent vehicle intravenously. The injection of saline never caused pain, but the solvent caused mild or moderate pain in 9 patients. I.C.I. 35868 was therefore reformulated in a 1% solution, excluding ethanol from the solvent. When intravenous injection of I.C.I. 35868 1% was compared to methohexitone 1% in 24 patients, both agents caused pain. Four out of 12 patients reveiving I.C.I. 35868 1% felt pain, with a total pain "score" of 6, but 6 out of 12 patients who received methohexitone 1%, felt pain, with a total pain "score" of 12. In no instance was intravenous injection followed by persistant pain, or evidence of thrombosis or phlebitis.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0001-5164
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
28
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
317-22
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:349998-Anesthesia, Intravenous,
pubmed-meshheading:349998-Anesthetics,
pubmed-meshheading:349998-Clinical Trials as Topic,
pubmed-meshheading:349998-Drug Evaluation,
pubmed-meshheading:349998-Humans,
pubmed-meshheading:349998-Injections, Intravenous,
pubmed-meshheading:349998-Methohexital,
pubmed-meshheading:349998-Pain,
pubmed-meshheading:349998-Pharmaceutical Vehicles,
pubmed-meshheading:349998-Phenols
|
pubmed:year |
1977
|
pubmed:articleTitle |
I.C.I. 35868 - The effect of a change of formulation on the incidence of pain after intravenous injection.
|
pubmed:publicationType |
Journal Article,
Clinical Trial
|