Linked Life Data

3499752

Source:http://linkedlifedata.com/resource/pubmed/id/3499752

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-12-8
pubmed:abstractText
Highly purified normal human tonsillar B lymphocytes were cultured with recombinant IL 2 (rIL 2). The responses were minimal when the cells were cultured with rIL 2 alone. Dose-dependent proliferation and differentiation into immunoglobulin-secreting cells were found when the cells were simultaneously activated with Staphylococcus aureus Cowan I (SAC). T cells were not found to proliferate in these cultures. B-cell responses were not augmented when 16% T cells were added to the B-cell population. In contrast, B-cell proliferation and Ig secretion were significantly enhanced by adding 0.5% T cells when cultured in the presence of pokeweed mitogen (PWM). Moreover, B-cell stimulation by rIL 2 was detected at very low cell densities. It is concluded that IL 2 directly affects the function of activated B cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0108-0202
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-72
pubmed:dateRevised
2009-6-4
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Recombinant interleukin 2 induces proliferation and differentiation of human B lymphocytes.
pubmed:affiliation
Department of Medical Microbiology, Turku University, Finland.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't