| pubmed-article:3499499 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3499499 | lifeskim:mentions | umls-concept:C0121772 | lld:lifeskim |
| pubmed-article:3499499 | lifeskim:mentions | umls-concept:C0231330 | lld:lifeskim |
| pubmed-article:3499499 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:3499499 | lifeskim:mentions | umls-concept:C0206515 | lld:lifeskim |
| pubmed-article:3499499 | lifeskim:mentions | umls-concept:C0205151 | lld:lifeskim |
| pubmed-article:3499499 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3499499 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3499499 | pubmed:dateCreated | 1987-12-14 | lld:pubmed |
| pubmed-article:3499499 | pubmed:abstractText | A conjugate vaccine (Dpo20) was made by direct coupling of diphtheria toxoid and oligosaccharides obtained by periodate oxidation of Haemophilus influenzae type b capsular polysaccharide. This approach gave a higher multiplicity of saccharides per protein and greater immunogenicity in infancy than our previously studied conjugates. Thirty-three healthy infants received three sequential injections, and no serious side effects were observed. When Dpo20 was given with diphtheria-tetanus-pertussis vaccine at ages 2, 4, and 6 months, the geometric mean titer of anticapsular antibody rose to 5.9 micrograms/ml at age 7 months. Dpo20 given at 3, 5, and 7 months raised the mean to 3.2 micrograms/ml at 7 months (after two injections) and 15.4 micrograms/ml at 10 months. The antibodies included IgG and were bactericidal in vitro. Thus, antibody activities potentially protective against invasive H. influenzae b infections were induced in the most susceptible age range. The infants also became primed for mature-for-age responses to (unconjugated) polysaccharide vaccine given as a booster at age 12 months. | lld:pubmed |
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| pubmed-article:3499499 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3499499 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:3499499 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3499499 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:3499499 | pubmed:issn | 0022-3476 | lld:pubmed |
| pubmed-article:3499499 | pubmed:author | pubmed-author:AndersonPP | lld:pubmed |
| pubmed-article:3499499 | pubmed:author | pubmed-author:EdwardsKK | lld:pubmed |
| pubmed-article:3499499 | pubmed:author | pubmed-author:InselRR | lld:pubmed |
| pubmed-article:3499499 | pubmed:author | pubmed-author:PichicheroMM | lld:pubmed |
| pubmed-article:3499499 | pubmed:author | pubmed-author:PorchC RCR | lld:pubmed |
| pubmed-article:3499499 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3499499 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:3499499 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3499499 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3499499 | pubmed:pagination | 644-50 | lld:pubmed |
| pubmed-article:3499499 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:3499499 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3499499 | pubmed:articleTitle | Priming and induction of Haemophilus influenzae type b capsular antibodies in early infancy by Dpo20, an oligosaccharide-protein conjugate vaccine. | lld:pubmed |
| pubmed-article:3499499 | pubmed:affiliation | Department of Pediatrics, University of Rochester, NY. | lld:pubmed |
| pubmed-article:3499499 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3499499 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3499499 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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